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Friday, August 5, 2016

Protandim Nrf2 Synergizer Shown to Extend Median Lifespan in Mice

Science

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Quality of life. Everyone wants it, but what is it?

Depends on who you ask, and it’s likely you’ll get different answers from one person to the next. Nonetheless, most people agree that there are a few things that can largely impact quality of life – one being physical health.

Thanks to medical advances and improvements to the environment, average lifespan is now around 70 years old. But as people have started to live longer, it has become clear that quality of life trumps quantity (or length) of life. The reason being that with age comes a number of not-so-pleasant changes. Your muscles grow weak, your memory fades, your eyesight dwindles… the list goes on.

Yes, you likely become wiser as you grow older but the reality is, that just like everyone else, you face an inevitable physical decline. So unless you are able to ward off any changes that could get in the way of day-to-day life, living longer might not be a pleasant experience.

Healthy Lifespan

This idea – extending “healthy lifespan” – has led many scientists to explore what it is that’s happening inside of the body that ultimately leaves us looking gray and wrinkly, feeling tired and weak, and wondering if our memory will still be there when we wake up the next morning.

Currently, there are several theories that seek to explain the mechanisms responsible for aging. Most experts agree that how we age physically is due to a combination of these mechanisms. As such, each theory represents one piece of the aging puzzle – a puzzle that is far from being finished.

National Institute of Aging

One organization involved in aging research is the National Institute of Aging (NIA). Because of the large number of interventions on the market that claim to slow aging, the NIA developed an aging interventions testing program (ITP). This program examines diets, supplements and compounds with strong evidence to suggest their beneficial effects on aging. The NIA’s hope is to identify safe, inexpensive interventions that can promote healthy aging and as a result, help people to maintain quality of life.

Interventions Testing Program

Studies are conducted in three research laboratories: Jackson Laboratories, the University of Michigan, and the University of Texas Health Sciences Center at San Antonio.

The ITP Access Committee evaluates many applications for testing and chooses only about five proposals every year for testing in these research laboratories. Researchers carefully conduct these experiments and strictly evaluate the results to determine whether the chosen interventions slow aging and postpone late life diseases in a special population of mice.

Phase I Studies – Look at the effects of the intervention on lifespan.

Phase II Studies – Because lifespan is not the only (or the best) measurement of effectiveness of an intervention to promote healthy aging, those interventions that prove to significantly impact lifespan and overall health in Phase I studies go onto Phase II.

During Phase II, other physiological, biochemical and behavioral measurements are taken. Additionally, another lifespan study is conducted. These studies help to –

  1. shed light on the physiological processes and biochemical pathways that might be connected to the aging process, and
  2. verify the effects of the intervention on lifespan.

Positive findings from the ITP

Since the start of the NIA’s program to test interventions hypothesized to increase healthy lifespan, only 6 compounds have shown promising outcomes. Out of the 6 compounds, Protandim Nrf2 Synergizer is the only nutritional supplement, the others are classified as drugs.

Why did they study Protandim?

Part of the reason Protandim was chosen was because of previous studies that have shown great results. These previous studies, which are quoted in this published study, showed that Protandim:

  • Provides strong Nrf2 activation with minimal side effects (Velmurugan et al., 2009).
  • Increases superoxide dismutase in red blood cells by 30% and increases catalase by 54% (Nelson et al, 2006).

What else did the study find?

Other findings from the study are as follows:

  • “These results suggest that Nrf2 activation may contribute to the stress resistance and increased longevity observed.”
  • “Protandim, a mixture of botanical extracts that activate Nrf2, extended median lifespan . . .”
  • “There was a significant effect (P<0.012) of [Protandim] on survival of male mice in the pooled population, with a 7% increase in median survival.”
  • The study “supports the idea that the effects of [Protandim] on longevity may be at least partly due to Nrf2 activation.”
  • “These results suggest that Nrf2 activation may contribute to the stress resistance and increased longevity observed . . .”
  • The study results suggest that “the effects of [Protandim] are most beneficial earlier in life.”

How did they perform the study?

Scientists started feeding a chow containing Protandim to a group of mice when they were 10 months old. They used an amount that they thought would be approximately the same, by proportional weight, as a human would consume. When the mice reached 17 months of age, they doubled the amount of Protandim. The scientist then observed the mice over their lifespan, until their natural death, comparing them to a control group which ate a chow that did not contain Protandim.

Will they do more studies?

The scientists who performed this study suggested that these future studies might be helpful:

  • Examining the effects of higher and lower doses of Protandim than the doses that they used.
  • Studying the response to Protandim over a lifespan to determine what mechanisms in the body Protandim affects both earlier and later in life.

What it all means?

The findings from this study not only validate the efficacy of Protandim Nrf2 Synergizer but also provide evidence that the supplement’s main mechanism of action, Nrf2 activation, might have a positive effect on lifespan. That said, more research is needed to 1) establish consistent findings; 2) shed light on the mechanisms by which Protandim has its effect on lifespan and; 3) ensure similar findings in humans.

This study confirms what we’ve known about Protandim Nrf2 Synergizer for years – that it is the most powerful anti-aging supplement on the market. By minimizing oxidative stress and boosting cellular health, Protandim Nrf2 Synergizer offers a safe, scientifically-proven method that can help people to maintain optimal health as they age.


Read the Full Study
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an a-glucosidase inhibitor or a Nrf2-inducer. Aging Cell (2016) pp1–13.

Learn More About the NIA’s Interventions Testing Program

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